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Anti-IGFBPL1
IGFBPL1抗体
详询
兔
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见产品详情
IgG
冻干或液体
见产品详情
-20℃
1mg/ml
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英文名称 Anti-IGFBPL1 |
中文名称 胰岛素样生长因子结合蛋白样1抗体 |
别 名 bA113O24.1; IGFBP-related protein 10; IGFBP-RP4; IGFBPRP4; insulin-like growth factor binding protein related protein 4; insulin-like growth factor-binding protein-like 1; IBPL1_HUMAN; insulin-like growth factor-binding-related protein 4. |
浓 度 1mg/1ml |
规 格 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep |
产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导 生长因子和激素 |
蛋白分子量 predicted molecular weight: 26kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human IGFBPL1 |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 IGFBPL1 is a secreted IGF (Insulin-like growth factor) binding protein that is known to contain an Ig-like C2-type (immunoglobulin-like) domain, an IGFBP N-terminal domain and a Kazal-like domain. IGF-binding proteins characteristically act to extend the half-life of IGFs and may influence the growth promoting effects of the IGFs. The interaction of IGFBPs with IGFs can affect cell surface receptors, specifically, IGFBPs may enhance or decrease a cells insulin sensitivity. IGFBPL1 has been found to be down-regulated in multiple tumors and thus may be a likely tumor suppressor candidate. Highly expressed in both brain and testis, IGFBPL1 is found at lower levels in the prostate, bladder and lung. |
Function : IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. |
Subcellular Location : Secreted. |
Tissue Specificity : Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. |
Similarity : Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
Contains 1 IGFBP N-terminal domain. |
Contains 1 Kazal-like domain. |
Database links : UniProtKB/Swiss-Prot: Q8WX77.1 |
Shiga-like toxin IIe variant subunit A[Escherichia coli] 抗猪水肿病大肠杆菌志贺样毒素Ⅱ型突变体(O139菌株)抗体 |
Anti-SHP-1 (SYT homology phosphatase-1) 造血细胞磷酸酶抗体 |
Anti-SHP2/PTPN11(SYT homology 2 (SH2) domain containing phosphotyrosinephosphatase 2) 蛋白酪氨酸磷酸酶2抗体 |
Anti-SIP1 (survival of motor neuron protein interacting protein 1) 运动神经元存活蛋白结合蛋白1抗体 |
Anti-Skp2 (S-phase kinase-associated protein 2,SKP2) 细胞S相激酶相关蛋白抗体 |
Anti-Slc22A17 (solute carrier famili 22A17) 可溶性载质转运蛋白22A17抗体 |
Anti-SLC24A5 (solute carrier family 24, member 5) 可溶性载质转运蛋白SLC24A5抗体 |
Anti-SLC6A19 (Solute carrier family 6, member 19) 钾依赖钠钙交换蛋白6 |
anti-Smac/DIABLO(the second mitochondrial activator of caspase) 线粒体促凋亡蛋白抗体 |
SLC34A2/NaPi-2b(Solute carrier family 34 member 2) 磷酸钠协同转运蛋白抗体 |
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