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- 2026年01月27日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IL-6R Beta/CD130/gp130
- 抗体名：
6R Beta/CD130/gp130抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
冻干或液体
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IL-6R Beta/CD130/gp130 |
| 中文名称 白细胞介素6受体β抗体IL-6Rβ |
| 别 名 Interleukin-6 receptor subunit beta; IL-6R-beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; CDw130; Oncostatin-M receptor subunit alpha; CD_antigen; CD130; GP130 RAPS; gp130 transducer chain; GP130-RAPS; IL6 ST; IL6R-beta; IL6ST.IL6R-beta. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导 细胞膜受体  |
| 蛋白分子量 predicted molecular weight: 99kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IL6R beta C-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Function : Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
| Subunit : Interacts with INPP5D/SHIP1. Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK. |
| Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. |
| Tissue Specificity : Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. |
| Post-translational modifications : Phosphorylation of Ser-782 down-regulates cell surface expression. |
| Heavily N-glycosylated. |
| Similarity : Belongs to the type I cytokine receptor family. Type 2 subfamily. |
| Contains 5 fibronectin type-III domains. |
| Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
Database links : UniProtKB/Swiss-Prot: P40189.2 |
| Anti-MrpL28 (mitochondrial ribosomal protein L28) 线粒体核糖体蛋白L28抗体 |
| Anti-MSH-2 (MutS homolog 2) 错配修复蛋白2抗体 |
| anti-MLH1(Mutl homolog l gene) 错配修复蛋白1抗体 |
| Anti-MSLN (mesothelin) 间皮素抗体 |
| anti-MUC5AC/Mucin 5AC(Gastric Mucin M1) 胃粘液素抗体 |
| Anti-MTR-1A (Melatonin receptor-1A) 褪黑素受体/松果体素受体抗体 |
| Anti-mucin-1/Muc-1/CD227 antigen (Epithelial Membrane Antigen ) 粘蛋白-1/上皮膜抗原抗体 |
| Anti-MyD88 (myeloid differential protein-88) 髓样分化蛋白抗体 |
| Anti-Myelin P0 protein( peripheral myelin prothein Zero;MPZ;MPP) 外周髓磷脂P0蛋白/P0蛋白抗体 |
| Anti-Myosin (Smooth Muscle) 鼠抗人心肌肌凝蛋白(平滑肌) 单抗 |
| Anti-N-AChR α4 (Nicotinic-Acetylcholine receptor α4) 碱型乙酰胆碱受体α4抗体 |
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