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优利科(上海)生命科学有限公司
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1年
Anti-IL-16
IL-16抗体
详询
兔
/
见产品详情
IgG
冻干或液体
见产品详情
-20℃
1mg/ml
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英文名称 Anti-IL-16 |
中文名称 白介素16抗体 |
别 名 Interleukin-16; HGNC:5980; HsT19289; Interleukin 16 precursor; LCF; Lymphocyte Chemotactic Factor; IL16; Lymphocyte chemoattractant factor; PrIL16; IL16_HUMAN. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat |
产品类型 一抗 |
研究领域 免疫学 |
蛋白分子量 predicted molecular weight: 13/76/147kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human IL-16 N-terminus |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 IL16 is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils. |
Function : Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. |
Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. |
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
Subunit : Homotetramer (Probable). Isoform 2 interacts with GRIN2A. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C.Isoform 2 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GABPB1. Isoform 2 interacts (via PDZ 3 domain) with HDAC3 (By similarity). |
Subcellular Location : Secreted (By similarity). Isoform 1: Cytoplasm. Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites. Isoform 2: Cytoplasm. Nucleus (By similarity). |
Tissue Specificity : Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung. |
Post-translational modifications : Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. |
Similarity : Contains 4 PDZ (DHR) domains. |
Database links : UniProtKB/Swiss-Prot: Q14005.4 |
GDNF (Glial cell line-derived neurotrphic factor) 胶质细胞源性神经营养因子抗原 |
GFP (Green Fluorecent protein) 绿色荧光蛋白多肽抗原 |
GROα/GRO/MGSA/CXCL1 protein (growthregulated oncogene α) 生长调节致癌基因α/黑素瘤生长刺激因子α 抗原 |
Haase(hyaluronidase) 透明质酸酶/玻璃酸酶抗原 |
HA tag HA tag标签蛋白 |
HBA1(hemoglobin alpha 1) 人类血红蛋白α1抗原 |
HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
HHV8/ORF K2(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
anti-HMGA1 (high mobility group AT-hook 1) 高迁移率族蛋白A1抗原 |
HMGA2 (high mobility group A2) 高迁移率族蛋白A2抗原 |
HO-1/HSP32 (Hemeo xygenase 1) 血红素氧合酶-1/热休克蛋白-32抗原 |
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