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Anti-IL-12RB1/CD212
12RB1/CD212抗体
详询
兔
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见产品详情
IgG
冻干或液体
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-IL-12RB1/CD212 |
中文名称 白细胞介素-12受体β1抗体 |
别 名 Interleukin-12 receptor subunit beta-1; IL12RB1; CD212; IL-12R-BETA1; IL12RB; MGC34454; "IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12RB1; IL-12R-beta-1; IL-12R subunit beta-1; IL-12 receptor subunit beta-1; I12R1_MOUSE. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Mouse, Rat |
产品类型 一抗 |
研究领域 细胞生物 免疫学 细胞膜受体 |
蛋白分子量 predicted molecular weight: 80kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-12RB1 C-terminus |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. |
Function : Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
Subunit : Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor. |
Subcellular Location : Membrane; Single-pass type I membrane protein. |
Similarity : Belongs to the type I cytokine receptor family. Type 2 subfamily. |
Contains 5 fibronectin type-III domains. |
Database links : UniProtKB/Swiss-Prot: Q60837.2 |
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Anti-PCNA(Proliferation Cell Nuclear Antigen) 增殖细胞核抗原抗体 |
anti-PDE4D(phosphodiesterase 4D) 磷酸二酯酶4D抗体 |
Anti-PDGF-A 血小板源性生长因子-A抗体 |
Anti-PDGF-B 血小板源性生长因子-B抗体 |
Anti-PDGF-BB((platelet derived growth factor-BB) 血小板源性生长因子-BB抗体 |
Anti-PDGF-R-A 血小板源性生长因子受体-A抗体 |
Anti-PDGF-R-B 血小板源性生长因子受体-B抗体 |
Anti-Pdk4(pyruvate dehydrogenase kinase isozyme 4) 丙-酮酸脱氢酶激酶4抗体 |
anti-Pdx1(pancreatic and duodenal homeobox 1) 胰十二指肠同源异型盒基因抗体 |
Anti-PEDF (pigment epithelium-derived factor) 色素上皮源性因子抗体 |
Anti-PEG10 (Paternally expressed gene 10) 肝癌高表达基因抗体 |
Anti-PEPT1 (Peptide-transporters 1) 肠道肽转运蛋白1/小肽转运蛋白1抗体 |
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