- ￥1280 - 1980
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
55
- 靶点：
/
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IL-2R gamma/CD132
- 抗体名：
IL-2R gamma/CD132抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IL-2R gamma/CD132 |
| 中文名称 白介素2受体γ链抗体 |
| 别 名 IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; common cytokine receptor gamma chain; Gamma C; gamma(c); IL-2R gamma chain; IL2RG; IMD4; interleukin 2 receptor, gamma; P64; SCIDX; SCIDX1. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导 细胞膜受体  |
| 蛋白分子量 predicted molecular weight: 41kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IL-2R gamma C-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. |
| In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. |
| The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency (X SCID), a disease that is characterized by the absence of T cells and NK cells. |
| Subunit : The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. |
| Subcellular Location : Membrane; Single-pass type I membrane protein. |
Similarity : Contains 1 fibronectin type-III domain. |
| GHR (growth hormone receptor) 生长激素受体(抗原) |
| GLUT1(Glucose transporter type 1） 葡萄糖转运蛋白1（抗原） |
| hypothetical protein （LOC55652) hypothetical protein 抗原 |
| HCCR-1(BRI3 binding protein) 人宫颈癌基因/bri3结合蛋白(抗原) |
| pre S1/S2 protein [HBV] 乙肝病毒pre S1/乙肝病毒pre S2(抗原) |
| HCV-HCBP1/ACY-3(Hepatitis C virus core-binding protein 1) 丙型肝炎病毒核心蛋白结合蛋白-1（抗原） |
| HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
| HHV8/ORF K2/vIL-6(Human herpesvirus 8) 人类疱疹病毒8抗原 |
| HIF-1α （Hypoxia-inducible factor -1α） 缺氧诱导因子1α （抗原） |
| HIV gp41 艾滋病病毒（抗原） |
| histone H3-like protein 抗组蛋白H3样抗原 |
| histone H3-like protein 抗组蛋白H3样蛋白（C端抗原） |
| histone H3-like protein 抗组蛋白H3样蛋白（N端抗原） |
| HIV-1（human immunodeficiency virus type 1） 艾滋病病毒-1/人类免疫缺陷病毒1型(抗原) |
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白介素2受体γ链抗体
￥1280 - 1980
