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Anti-IGFBP4/IBP4
IGFBP4/IBP4抗体
详询
兔
/
见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-IGFBP4/IBP4 |
中文名称 胰岛素样生长因子结合蛋白4抗体 |
别 名 Insulin-like Growth Factor Binding Protein 4; BP 4; BP4; HT29 IGFBP; IBP 4; IBP4; IGF binding protein 4; IGFBP 4; IBP4_HUMAN. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep |
产品类型 一抗 |
研究领域 肿瘤 免疫学 生长因子和激素 转录调节因子 糖尿病 |
蛋白分子量 predicted molecular weight: 26kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human IGFBP4 |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 Insulin like growth factor binding protein 4 (IGFBP4) is produced from a DNA sequence encoding the human IGFBP4 protein. Mature human IGFBP4 has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, the recombinant protein migrates as a 32 kDa and 25 kDa protein under reducing and non reducing conditions, respectively. Human IGFBP4 has a potential N-linked glycosylation site and shares approximately 90% amino acid sequence identity with both mouse and rat IGFBP4. IGFBP4 is a member of the superfamily of insulin-like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). IGFBP4 functions as an inhibitor of IGF action and its main function may be to protect cells from overstimulation by IGFs or to allow activation of alternate transmembrane signaling pathways that are inhibited by IGF exposure. IGFBP4 is expressed in multiple tissues including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex. |
Function : IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
Subunit : Binds IGF2 more than IGF1. |
Subcellular Location : Secreted. |
Similarity : Contains 1 IGFBP N-terminal domain. |
Contains 1 thyroglobulin type-1 domain. |
Database links : UniProtKB/Swiss-Prot: P22692.2 |
生长因子和激素( Growth Factor and Hormones) |
IGFBP5胰岛素样生长因子结合蛋白4(IGFBP-4)是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGFBP-4与IGFs结合可以调节IGFs与IGF-I型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用. |
Socs 1 (suppressor of cytokine signaling 1) 细胞激酶信号-1抑制剂(抗原) |
SM-MHC(Cardiac myosin heavy chain) 心肌肌凝蛋白多肽 |
α-Synuclein 核突触蛋白(抗原) |
α-Synuclein 核突触蛋白(抗原) |
SuYTtance P Receptor (Neurokinin receptor1;Tachykinin receptor1) P物质受体(抗原) |
SuYTtance-K receptor(SKR)Neurokinin A receptor(NK-1R) 神经激肽A受体(抗原) |
Tanis/SELS (Selenoprotein S)又称SELS 炎症负调控因子蛋白(抗原) |
Tau protein 微管相关蛋白(抗原) |
Telomerase (TE) 端粒酶(催化亚单位)(多肽抗原) |
TGF-α (Ttansforming Growth Factor –α) 转移生长因子–α(抗原) |
TGF-β1 (Ttansforming Growth Factor –β1) 转移生长因子–β1(抗原) |
TGF-β2 (Ttansforming Growth Factor –β2) 转移生长因子–β2(抗原) |
TGF-β3 (Ttansforming Growth Factor –β3) 转移生长因子–β3(抗原) |
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