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优利科(上海)生命科学有限公司
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多克隆
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1年
Anti-IRS-4
IRS-4抗体
详询
兔
/
见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-IRS-4 |
中文名称 胰岛素受体底物-4抗体 |
别 名 IRS4; 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS 4; PY160. |
浓 度 1mg/1ml |
规 格 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Mouse, Rat |
产品类型 一抗 |
研究领域 信号转导 |
蛋白分子量 predicted molecular weight: 134kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from mouse IRS-4 N-terminus |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 IRS4 (Insulin receptor substrate 4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signaling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. |
Function : Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2. |
Subunit : Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH. Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2. |
Subcellular Location : Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
Tissue Specificity : Expressed in skeletal muscle, brain, heart, kidney and liver. |
Post-translational modifications : Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-894 in response to FGF2 signaling. Phosphorylation of Tyr-894 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction. |
Similarity : Contains 1 IRS-type PTB domain. |
Contains 1 PH domain. |
胰岛素受体底物-4属于IRS家族。IRS作为insulin/IGF 信号途径的核心介子对细胞的生长、发育及新陈代谢的调节起关键作用。 |
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