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优利科(上海)生命科学有限公司
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科研
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1年
Anti-Insulin precursor/Proinsulin
Insulin precursor/Proinsulin抗体
详询
兔
/
见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-Insulin precursor/Proinsulin |
中文名称 胰岛素原抗体 |
别 名 INS_HUMAN; ILPR; INS; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit |
产品类型 一抗 |
研究领域 肿瘤 心血管 细胞生物 神经生物学 信号转导 生长因子和激素 糖尿病 内分泌病 新陈代谢 |
蛋白分子量 predicted molecular weight: 5.8/12kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human Insulin |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76% sequence identity and are 50% related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined. |
Function : Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
Subunit : Heterodimer of a B chain and an A chain linked by two disulfide bonds. |
Subcellular Location : Secreted. |
DISEASE : Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730]. |
Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic dieresis and secondary thirst. These derangements result in long-term complications that |
Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. |
Similarity : Belongs to the insulin family. |
Database links : UniProtKB/Swiss-Prot: P01308.1 human |
胰岛素(Isulin)胰岛素抗体是胰岛细胞分泌得一种激素,可以减底血糖浓度。此抗体和人胰岛素反应,并与大多数哺乳类动物的胰岛素有交叉反应,主要用于胰岛细胞瘤的功能性研究。 |
Anti-Nurr1 核受体相关因子-1抗体 |
Anti-OAS1(2',5'-oligoadenylate synthetase 1) 寡腺苷酸合成酶-1 |
Anti-OAT-1 (Organic anion transporter 1)human 阴离子转运蛋白-1(抗人;YT-0607R 抗大、小鼠) |
Anti-OAT-1 (Organic anion transporter 1)mouse、rat 阴离子转运蛋白-1(抗大、小鼠:YT-0606R 抗人) |
Anti-OAT-3(Organic anion transporter 3) 阴离子转运蛋白-3抗体 |
Anti-OAT4L/URAT1 (Urate Transporter 1) 尿酸盐重吸收转运子1抗体 |
Anti-OCT1 (organic cat-ion transporter1) 阳离子转运器1抗体 |
Anti-OCT2 (organic cat-ion transporter2) B细胞特异性转录因子抗体 |
Anti-Oct-4 antibody 胚胎干细胞关键蛋白抗体 |
anti-ODC(Ornithine decarboxylase) 抗鸟氨酸脱羧酶抗体 |
Anti-Omgp (olyigodendrocyte myelin glycoprotein) 少突细胞髓磷脂糖蛋白抗体 |
Anti-OPCML (opioid binding protein/cell adhesion molecule-like) a片样物质结合蛋白/细胞粘附分子样蛋白抗体 |
Anti-OPG (Osteoprotegerin) 骨保护蛋白/护骨素抗体 |
Anti-OPGL/RANKL (Osteoprotegerin ligand) 骨保护蛋白配体抗体 |
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