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- 2026年01月27日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IL-1 Beta/IL-1B
- 抗体名：
IL-1 Beta/IL-1B抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IL-1 Beta/IL-1B | |||||||||||||||
| 中文名称 白介素1β/IL-1β抗体 | |||||||||||||||
| 别 名 Catabolin; H1; IL-1β; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL1B; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; LAF; OAF; Osteoclast activating factor; Preinterleukin beta; Pro interleukin 1 beta; IL1B_HUMAN; Interleukin-1 beta; IL-1 beta. | |||||||||||||||
| 浓 度 1mg/1ml | |||||||||||||||
| 规 格 0.1ml/100μg 0.2ml/200μg 1ml/1mg | |||||||||||||||
| 抗体来源 Rabbit | |||||||||||||||
| 克隆类型 polyclonal | |||||||||||||||
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit, Guinea Pig | |||||||||||||||
| 产品类型 一抗 | |||||||||||||||
研究领域 细胞生物 免疫学 糖蛋白  |
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| 蛋白分子量 predicted molecular weight: 17kDa | |||||||||||||||
| 性 状 Lyophilized or Liquid | |||||||||||||||
| 免 疫 原 KLH conjugated synthetic peptide derived from human IL-1beta | |||||||||||||||
| 亚 型 IgG | |||||||||||||||
| 纯化方法 affinity purified by Protein A | |||||||||||||||
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide | |||||||||||||||
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 | |||||||||||||||
| （石蜡切片需做抗原修复） | |||||||||||||||
| not yet tested in other applications. | |||||||||||||||
| optimal dilutions/concentrations should be determined by the end user. | |||||||||||||||
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. | |||||||||||||||
| 产品介绍 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. | |||||||||||||||
| Function : Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | |||||||||||||||
| Subunit : Monomer. | |||||||||||||||
| Subcellular Location : Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. | |||||||||||||||
| Similarity : Belongs to the IL-1 family. | |||||||||||||||
| Database links : | |||||||||||||||
| UniProtKB/Swiss-Prot: P01584. | |||||||||||||||
| Entrez Gene: 16176 Mouse | |||||||||||||||
| Entrez Gene: 24494 Rat | |||||||||||||||
| SwissProt: P10749 Mouse | |||||||||||||||
| SwissProt: Q63264 Rat | |||||||||||||||
| Unigene: 222830 Mouse | |||||||||||||||
| Unigene: 9869 Rat | |||||||||||||||
| 生长因子和激素（ Growth Factor and Hormones） | |||||||||||||||
| IL-1β是一种糖蛋白，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要做 用。 | |||||||||||||||
IL-1β前体在细胞内合成后被酶剪切为成熟形态后排出到细胞外,IL-1β的前体有153个氨基酸。成熟形态有116个氨基酸。
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