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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IL-18/IGIF
- 抗体名：
IL-18/IGIF抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IL-18/IGIF |
| 中文名称 白细胞介素-18/干扰素γ诱导因子抗体 |
| 别 名 interferon gamma-inducing factor IGIF; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; Iboctadekin; IFN gamma inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL1 gamma; IL18 protein; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin 18; Interleukin18; MGC12320; IL18_MOUSE. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Mouse, Rat |
| 产品类型 一抗 |
研究领域 免疫学  |
| 蛋白分子量 predicted molecular weight: 17kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-18 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. |
| IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions. |
| Function : Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. |
| Subcellular Location : Secreted. |
| Similarity : Belongs to the IL-1 family. |
| Database links : UniProtKB/Swiss-Prot: P70380.2 mouse |
IL-18是巨噬细胞分泌的一个重要因子，它具有多种免疫功能，能诱导产生ＩＦＮγ，无论在感染早期或特异性细胞免疫应答效应阶段都会出现，因此IL-18主要参与免疫应答及炎性细胞浸润的改变。Interleukin-18 又称inteferon-gamma inducing factor(IGIF)，在辅助T细胞的应答反应中起重要作用。IL-18和IL-1一起，既参与先天免疫，又是后天免疫的构成因素。 |
| CD147/EMMPRIN(Extracellular matrix metalloproteinase inducer) CD147(抗原) |
| CD169/sialoadhesin（Sn）(Sialic acid-binding Ig-like lectin 1；Siglec-1) CD169抗原 |
| CD272/BTLA(B and T lymphocyte attenuator) B 和 T 淋巴细胞衰减蛋白(抗原) |
| CDK2 (Cyclin-Dependent Kinase 2) 周期素依赖激酶2(抗原) |
| CDK4(Cyclin Dependent Kinase 4) 周期素依赖性激酶4(抗原) |
| CEA （CaYTinoembryonic Antigen ） 人癌胚抗原（抗原） |
| ChRM2 (Muscarinic Acetylcholine receptor M2) 毒蕈碱型乙酰胆碱受体M2（抗原） |
| Connexin-43(Cx43) 间隙连接蛋白43(多肽片断抗原) |
| Connexin-45(CX45) 间隙连接蛋白45(抗原) |
| Connexin-45(CX45) 缝隙连接蛋白45(抗原) |
| Anti-Collagen II II 型胶原(抗原) |
| CXCR1 (CXC-chemokine receptor 1) 细胞表面趋化因子受体1抗原 |
| COX-2 (Prostaglandin-endoperoxide synthase-2) 前列腺素氧化环化酶2(抗原) |
| c-phycocyanin(C-PC) C-藻蓝素(藻蓝蛋白) |
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文献和实验CD11a/CD11b/CD11c 分子 CDlla 常用单克隆抗体或代号：MHM24， 2F12； CRIS―3(LFA―lα链，整合素α1) 主要表达细胞：Leu[A5] 分子质量(kDa)和结构：spl80(整合素α) 功 能：与1CAM-l(CD54)、ICAM-2(CDl02)、ICAM-3(C1350)结合，介导细胞黏附；与JAMl结合，参与白细胞穿过内皮细胞
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