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Anti-IL-13
IL-13抗体
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兔
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见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
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英文名称 Anti-IL-13 |
中文名称 白介素13抗体 |
别 名 ALRH; BHR 1; BHR1; IL 13; IL13; Interleukin 13; Interleukin13; MGC116786; MGC116788; MGC116789; NC30; P600; IL13_MOUSE; Interleukin-13; IL-13; T-cell activation protein P600. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep |
产品类型 一抗 |
研究领域 肿瘤 细胞生物 免疫学 |
蛋白分子量 predicted molecular weight: 12kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-13 (45-56aa) |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 Human IL13 was originally identified by differential screening of an anti CD28 activated human peripheral blood mononuclear cell cDNA library as an induction specific novel cytokine. It was also isolated from cDNA libraries of human T cell clones using the murine IL13 (P600) cDNA as a probe. Human IL13, a pleiotropic cytokine, is produced by activated Th0, Th1 like, Th2 like, and CD8 T cells. The gene for human IL13 maps to chromosome 5 and is closely linked to the genes for IL3, IL4, IL5, and GMCSF. |
IL13 inhibits proinflammatory cytokine production and stimulates antibody production. It induces proliferation in the human pre myeloid cell line TF1. IL13 has multiple effects on the differentiation and functions of monocytes and macrophages. It suppresses cytotoxic functions and induces changes in the morphology of human monocytes and in the phenotype of human monocytes and B cells by upregulating MHC class II expression. IL13 will also decrease the production of nitric oxide by activated murine macrophages, leading to impaired parasiticidal activity. |
Human and mouse interleukin 13 share approximately 58% amino acid sequence identity. Although human and mouse IL13 are equally active on human cells, human IL13 is much less active than mouse IL13 on mouse cells. Human IL13 and human IL4 also share approximately 30% sequence homology and have similar biological functions. |
Function : Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. |
Subcellular Location : Secreted. |
DISEASE : Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. |
Similarity : Belongs to the IL-4/IL-13 family. |
Database links : |
Entrez Gene: 3596 Human |
Entrez Gene: 16163 Mouse |
Entrez Gene: 116553 Rat |
Omim: 147683 Human |
SwissProt: P35225 Human |
SwissProt: P20109 Mouse |
SwissProt: P42203 Rat |
Unigene: 845 Human |
Unigene: 1284 Mouse |
Unigene: 9921 Rat |
生长因子和激素( Growth Factor and Hormones) |
IL-13是由T细胞、嗜碱粒细胞、浆细胞及树突状细胞产生的细胞因子。 |
IL-13诱导、维持一定IgE水平,增强巨噬细胞及树突状细胞活性,活化嗜酸粒细胞并防止其凋亡,广泛参与过敏性及炎性疾病过程。 |
L-HDC (L-Histidine decarboxylase) L-组氨酸脱羧酶抗原 |
LFABP/FABP-1(Liver Fatty acid binding protein) 肝脏型脂肪酸结合蛋白抗原 |
LN (laminin) 层粘连蛋白(多肽抗原) |
ACE( ACE, testis-specific isoform precursor) 血管紧张素转换酶(抗原) |
Mac-1 (Mac-1/CR3/CD11b+CD18) 巨噬细胞表面分子抗原 |
MAGE-1 antibody (Melanoma antigen Recognized by T-cells 1) 黑色素瘤相关抗原 |
Maspin (mammary serine protease inhibitor) 抑癌基因抗原 |
Matriptase 蛋白裂解酶(一种新的癌基因)抗原 |
Mfn1 (Mitofusin1) 线粒体融合蛋白1 |
MGr1-Ag/37LRP(P37-kDa laminin receptor precursor) 层粘连蛋白受体1抗体 |
MIF (Macrophage Migration Inhibitory Factor) 巨噬细胞移动抑制因子抗原 |
MrpL28 (mitochondrial ribosomal protein L28) 线粒体核糖体蛋白L28(抗原) |
MUC5AC/Mucin 5AC(Gastric Mucin M1) 胃粘液素抗原 |
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