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单克隆
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1年
Anti-IFN gamma(F2E4)
IFN gamma(F2E4)抗体
详询
Mouse
/
见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-IFN gamma(F2E4) |
中文名称 γ-干扰素/γ-IFN单克隆抗体 |
别 名 IFNG; IFG; IFI; IFN Gamma; IFN Immune; IFN-gamma; IFNG; IFNG_HUMAN; Immune Interferon; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; Type II Interferon. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg |
抗体来源 Mouse |
克隆类型 monoclonal |
克 隆 号 F2E4 |
交叉反应 Human |
产品类型 一抗 |
研究领域 肿瘤 免疫学 细菌及病毒 |
蛋白分子量 predicted molecular weight: 17kDa |
性 状 Lyophilized or Liquid |
免 疫 原 Full length of human IFN gamma |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 Mammalian Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2. |
Function : Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
Subunit : Homodimer. |
Subcellular Location : Secreted. |
Tissue Specificity : Released primarily from activated T ymphocytes. |
Post-translational modifications : Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. |
DISEASE : In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. |
Similarity : Belongs to the type II (or gamma) interferon family. |
Database links : UniProtKB/Swiss-Prot: P01579.1 human |
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