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Anti-IL-12
IL-12抗体
详询
兔
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见产品详情
IgG
冻干或液体
见产品详情
-20℃
1mg/ml
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英文名称 Anti-IL-12 |
中文名称 白介素12抗体 |
别 名 IL12; CLMF p35; CLMF1; CTL maturation factor (TcMF); Cytotoxic lymphocyte maturation factor 1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL 12 subunit p35; IL12A; Interleukin 12 alpha chain; Interleukin 12 p35; Interleukin 12A; Natural killer cell stimulatory factor 1; NK cell stimulatory factor chain 1; NKSF1; p35; IL12A_HUMAN. |
浓 度 1mg/1ml |
规 格 0.1ml/100μg 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human |
产品类型 一抗 |
研究领域 肿瘤 细胞生物 免疫学 |
蛋白分子量 predicted molecular weight: 23kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human IL-12 C-terminus |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. |
Function : Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
Subunit : Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12. |
Subcellular Location : Secreted. |
Similarity : Belongs to the IL-6 superfamily. |
Database links : |
UniProtKB/Swiss-Prot: P29459.2 |
Entrez Gene: 3592 Human |
Entrez Gene: 3593 Human |
Omim 161560 Human |
Omim: 161561 Human |
SwissProt: P29459 Human |
SwissProt: P29460 Human |
Unigene: 673 Human |
Unigene: 674 Human |
IL-12是新近发现的细胞因子,具有多种生物学活性,尤其是在抗肿瘤免疫和抗免疫中有重要的作用。 |
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