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优利科(上海)生命科学有限公司
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1年
Anti-IBRDC2/RNF144B
IBRDC2/RNF144B抗体
详询
兔
/
见产品详情
IgG
Lyophilized or Liquid
见产品详情
-20℃
1mg/ml
详询
英文名称 Anti-IBRDC2/RNF144B |
中文名称 E3泛素蛋白连接酶144B/环指蛋白144B抗体 |
别 名 E3 ubiquitin protein ligase RNF144B; RING finger protein 144B; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain containing protein 2; IBR domain-containing protein 2; IBRDC 2; IBRDC2; p53 inducible RING finger protein; p53-inducible RING finger protein; p53RFP; PIR2; R144B_HUMAN; Ring finger 144B; RING finger protein 144B; RNF 144B; RNF144B. |
浓 度 1mg/1ml |
规 格 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep |
产品类型 一抗 |
研究领域 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 |
蛋白分子量 predicted molecular weight: 34kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human IBRDC2/RING finger protein 144B |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. |
Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. |
Function : E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. |
Subunit : Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX. |
Subcellular Location : Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. |
Tissue Specificity : Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. |
Post-translational modifications : Auto-ubiquitinated. |
Similarity : Belongs to the RBR family. RNF144 subfamily. |
Contains 1 IBR-type zinc finger. |
Contains 2 RING-type zinc fingers. |
Database links : UniProtKB/Swiss-Prot: Q7Z419.1 |
CT (Calcitonin ) 降钙素(抗原) |
CT-R (Calcitonin receptor) 降钙素受体(抗原) |
Cytochrome C 细胞色素 C(抗原) |
Cytomegalovirus (CMV)PP65 细胞巨化病毒(多肽) |
DDC (DOPA decarboxylase) 多巴胺脱羧酶(抗原) |
EGFR-ⅤⅢ 人表皮生长因子受体-8(多肽片断抗原) |
Endothelin-1 内皮素-1(多肽抗原) |
Endothelin-1 (ET-1) 内皮素-1(抗原) |
ERAB 内质网Aβ相关结合蛋白(抗原) |
ER-α(Estrogen) 雌激素受体(抗原) |
TIMP-1(Tissue Inhibitor of Metalloproteinase-1) 金属蛋白酶组织抑制因子-1(抗原) |
ER-α/β Estrpgen Receptor α/β 雌激素受体(抗原) |
ER-β Estrogen receptor 雌激素受体(抗原) |
EXPB-2 植物延展素-β(抗原) |
factor VIII 第八因子相关抗原(多肽片断抗原) |
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