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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
100
- 靶点:
详询
- 级别:
科研
- 目录编号:
/
- 克隆性:
多克隆
- 抗原来源:
详见说明书
- 保质期:
1年
- 抗体英文名:
Anti-Integrin alpha 4/CD49d/Integrin α4
- 抗体名:
Integrin alpha 4/CD49d/Integrin α4 抗体
- 标记物:
详询
- 宿主:
兔
- 适应物种:
/
- 免疫原:
见产品详情
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
见产品详情
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
详询
| 英文名称 Anti-Integrin alpha 4/CD49d/Integrin α4 |
| 中文名称 整合素α4抗体 |
| 别 名 Alpha 4 subunit of VLA 4 receptor;ITG-α4: Antigen CD49D; CD 49d ; CD49d; CD49d antigen; CDw49d; IA4; Integrin alpha IV; ITGA 4; ITGA4; LPAM23; MGC90518; Very Late Activation Antigen 4; Very Late Activation Protein 4 Receptor Alpha 4 Subunit; VLA 4; VLA4; integrin alpha-4; ITA4_HUMAN. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导 干细胞 细胞粘附分子 |
| 蛋白分子量 predicted molecular weight: 111kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human Integrin alpha 4 C-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 |
| (石蜡切片需做抗原修复) |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
| 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ![]() |
| 产品介绍 Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery. |
| Function : Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. |
| Subunit : Heterodimer of an alpha and a beta subunit. |
| Subcellular Location : Membrane; Single-pass type I membrane protein. |
| Post-translational modifications : Phosphorylation on Ser-1027 inhibits PXN binding. |
| Similarity : Belongs to the integrin alpha chain family. |
| Contains 7 FG-GAP repeats. |
| Database links : UniProtKB/Swiss-Prot: P13612.3 |
整合素-α-4型 Integrin α4 (CD49d)整合素-α是介导细胞与细胞外基质粘附作用的主要因子。![]() |
| Anti-MMP-2(Collagenase IV /Gelatinase A/Metallo proteinase-2) 基质金属蛋白酶-2抗体 |
| Anti-MMP-3(matrix metalloproteinase-3/Transin-1/SL-1/Stromelysin-1 precursor) 基质金属蛋白酶-3抗体 |
| Anti-MMP-7(Matrilysin/matrix metalloproteinases-7) 基质金属蛋白酶-7抗体 |
| Anti-MMP-9(matrix metalloproteinase 9) 基质金属蛋白酶-9抗体 |
| Anti-β-2-MG 鼠抗人β2微球蛋白抗体(单抗) |
| Anti-Mo anti-KLH 小鼠抗血蓝蛋白抗体 |
| Anti-MOG (myelin oligo-dendrocyte glycoprotein-MOG) 髓鞘少树突胶质细胞糖蛋白抗体 |
| Anti-Mouse anti-human HAS 鼠抗人血清白蛋白单克隆抗体 |
| Anti-Mouse IgA 兔抗小鼠IgA抗体 |
| Anti-MPO (myeloperoxidase) 髓过氧化物酶抗体 |
| Anti-MRP1(Multidrug Resistanec-Associated Protein 1) 多药耐药相关蛋白1抗体 |
| Anti-MRP2 (multidrug resistance-associated protein2) 多药耐药相关蛋白2抗体 |
| Anti-MRP3(Multidrug Resistanec-Associated Protein 3) 多药耐药相关蛋白3抗体 |
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