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- YLKBIO
- YLK-KT2122D
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- 2026年01月21日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-phospho-IFNAR1(Ser535+Ser539)
- 抗体名：
phospho-IFNAR1(Ser535+Ser539)抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
KLH conjugated Synthesised phosphopeptide derived from human IFNAR1 around the phosphorylation site of Ser535+Ser539
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-phospho-IFNAR1(Ser535+Ser539) |
| 中文名称 磷酸化干扰素α受体抗体 |
| 别 名 IFN alpha REC; IFN alpha receptor; IFN alpha/beta Receptor alpha; IFN beta receptor; IFNAR; IFNAR1; IFRC; Interferon alpha/beta receptor alpha chain; INAR1_HUMAN . |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig |
| 产品类型 一抗 磷酸化抗体 |
研究领域 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子  |
| 蛋白分子量 predicted molecular weight: 61kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human IFNAR1 around the phosphorylation site of Ser535+Ser539 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 IFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines. |
| Function : Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. |
| Subunit : Belongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains. |
| Subcellular Location : Membrane. |
| Tissue Specificity : IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. |
| Post-translational modifications : Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. |
| Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2. |
Database links : UniProtKB/Swiss-Prot: P17181.3 |
| Secretin 分泌素（抗原） |
| Secretin receptor 分泌素受体（抗原） |
| Socs 1 (suppressor of cytokine signaling 1) 细胞激酶信号-1抑制剂（抗原） |
| SM-MHC（Cardiac myosin heavy chain） 心肌肌凝蛋白多肽 |
| α-Synuclein 核突触蛋白（抗原） |
| α-Synuclein 核突触蛋白（抗原） |
| SuYTtance P Receptor (Neurokinin receptor1;Tachykinin receptor1) P物质受体（抗原） |
| SuYTtance-K receptor（SKR）Neurokinin A receptor（NK-1R） 神经激肽A受体（抗原） |
| Tanis/SELS (Selenoprotein S)又称SELS 炎症负调控因子蛋白（抗原） |
| Tau protein 微管相关蛋白（抗原） |
| Telomerase （TE） 端粒酶（催化亚单位）（多肽抗原） |
| TGF-α (Ttansforming Growth Factor –α) 转移生长因子–α（抗原） |
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文献和实验细胞膜受体结合后，才能产生一系列的生物效应，对产生效应的机制有以下假说，一认为胰岛素可诱导第二信使的形成，它们模拟或具有胰岛素样的活性。二认为胰岛素与α-亚单位结合，移入胞内后可激活酪氨酸蛋白激酶，继而催化受体蛋白自身及胞内其他蛋白的酪氨酸残基磷酸化，因而启动了磷酸化的连锁反应（phosphorylation cascade）。三认为胰岛素可使葡萄糖 载体 蛋白（glucose transporter）和其他蛋白质从胞内重新分布到胞膜，从而加速葡萄糖的转运。
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