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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
100
- 靶点:
详询
- 级别:
科研
- 目录编号:
/
- 克隆性:
多克隆
- 抗原来源:
详见说明书
- 保质期:
1年
- 抗体英文名:
Anti-IFNAR1
- 抗体名:
IFNAR1抗体
- 标记物:
/
- 宿主:
兔
- 适应物种:
/
- 免疫原:
KLH conjugated synthetic peptide derived from human IFNAR1 (369-378aa)
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
详询
| 英文名称 Anti-IFNAR1 |
| 中文名称 干扰素α受体抗体 |
| 别 名 IFN alpha REC; IFN alpha receptor; Interferon Receptor alpha; IFN alpha/beta Receptor alpha; IFN beta receptor; IFNAR; IFNAR1; IFRC; Interferon alpha/beta receptor alpha chain; INAR1_HUMAN. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Cow, Sheep |
| 产品类型 一抗 |
研究领域 肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子 干扰素 ![]() |
| 蛋白分子量 predicted molecular weight: 61kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IFNAR1 (369-378aa) |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 |
| (石蜡切片需做抗原修复) |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. ![]() |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 IFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines. |
| Function : Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. |
| Subunit : Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2. Interacts with IFNAR2. |
| Subcellular Location : Membrane; Single-pass type I membrane protein. |
| Post-translational modifications : Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. |
| Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2. |
| Similarity : Belongs to the type II cytokine receptor family. |
| Contains 3 fibronectin type-III domains. |
Database links : UniProtKB/Swiss-Prot: P17181.3![]() |
| PI3K 磷脂酰肌醇激酶(抗原) |
| PLGF (Placenta growth factor) 小鼠胎盘生长因子(多肽抗原) |
| PLGF (Placenta growth factor) 胎盘生长因子(多肽抗原) |
| PLGF (Placenta growth factor fragment)(human) 人胎盘生长因子(多肽抗原) |
| PP-1 蛋白磷酸酯酶-1(抗原) |
| PPAR-delta (peroxisome proliferator-activated receptor) D型-过氧化酶活化增生受体(多肽) |
| PP-2A (protein phosphatase 2A) 蛋白质磷酸酶-2A(抗原) |
| PP-2A (protein phosphatase 2A) 蛋白质磷酸酶-2A(抗原) |
| PP-2B alpha 1 蛋白磷酸酯酶-2B 催化亚单位(抗原) |
| PR (Progestogerone receptor) 孕激素受体(抗原) |
| PS-1(NT),Presennillin-1(S182) 早老素蛋白-1(抗原) |
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