- ￥1280 - 1980
- YLKBIO
- YLK-KT2034D
- 国产
- 2026年01月21日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-Integrin alpha 2b/CD41
- 抗体名：
Integrin alpha 2b/CD41抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
KLH conjugated synthetic peptide derived from human Integrin alpha 2b
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 保存条件：
-20℃
- 浓度：
详询
- 规格：
详询
| 英文名称 Anti-Integrin alpha 2b/CD41 |
| 中文名称 血小板膜糖蛋白ⅡbⅢa抗体 |
| 别 名 Integrin alpha 2b,platelet glycoprotein IIb of IIb/IIIa complex; Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; CD41; CD41B; GPIIb; GTA; HPA3; CD 41; CD41; CD41 antigen; CD41a; CD41b; GP2b; GPalpha IIb; GPalphaIIb; Integrin alpha 2b; Integrin alpha IIb; Integrin alpha IIb precursor; ITGA 2B; ITGA2B; ITGAB; Platelet fibrinogen receptor alpha; Platelet fibrinogen receptor alpha subunit; Platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; Platelet specific antigen bak. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit |
产品类型 一抗  |
| 研究领域 心血管 细胞生物 免疫学 信号转导 干细胞 细胞粘附分子 |
| 蛋白分子量 predicted molecular weight: 125kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human Integrin alpha 2b |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. |
| Function : Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
| Subunit : Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. |
| Subcellular Location : Membrane. |
DISEASE : Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. |
| Anti-TSARG3（Testis and spermatogenesis related gene 3） 生精细胞凋亡相关基因3抗体 |
| Anti-TSARG4（Testis and spermatogenesis related gene 4） 生精细胞凋亡相关基因4抗体 |
| Anti-TSGF（Tumor Specific Growth Fanctor） 恶性肿瘤特异性生长因子抗体 |
| Anti-TSH(Mouse Anti-Human Thyroid stimulating hormone Monoclonal Antibody) 鼠抗人促甲状腺素单克隆抗体 |
| Anti-TSHR (Thyroid stimulating hormone receptor) 促甲状腺素受体抗体 |
| Anti-TSHR (Thyroid stimulating hormone receptor)（CT） 促甲状腺素受体抗体（C端） |
| Anti-TSHR (Thyroid stimulating hormone receptor)(NT) 促甲状腺素受体抗体（N端） |
| Anti-TSLC1 (tumor suppressor in lung cancer-1) 肺癌肿瘤阻抑基因1抗体 |
| Anti-TSLP(Thymic stromal lymphopoietin isoform 1) 淋巴细胞生成素-1抗体 |
| Anti-TTF-1 (Thyroid Transcription Factor-1) 甲状腺核转录因子-1/甲状腺特异增强子结合蛋白抗体 |
| Anti-TTF-2(thyroid transcription factor 2;forkhead box E1) 甲状腺转录因子-2抗体 |
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文献和实验人血小板膜糖蛋白ⅠbⅨα（GP-ⅠbⅨα/CD42b+CD42a）抗体
人血小板膜糖蛋白Ⅰb Ⅸα（GP- Ⅰb Ⅸα/CD42b+CD42a ）抗体 酶联免疫分析试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中血小板膜糖蛋白Ⅰb Ⅸα（GP- Ⅰb Ⅸα/CD42b+CD42a ）抗体 的含量。 实验原理： 本试剂盒应用双抗原夹心法测定标本中人血小板膜糖蛋白Ⅰ b Ⅸα（ GP- Ⅰ b Ⅸα /CD42b+CD42a ）抗体
血管壁上。进一步研究表明，这株单抗“封闭”的是GPⅠb，从而证实了GPⅠb就是血小板膜表面的vW因子受体部位。这项研究表明，单抗技术有助于血小板生理功能的研究。此后，国际上又有多种血小板单抗的研究报道，如作用于GPⅡb-Ⅲa复合物的7E3等。这些抗血小板单抗的基础实验和临床研究证明，GPⅡb-Ⅲa复合物是作为纤维蛋白原的受体在血小板聚集过程中起重要作用；GPⅠa-Ⅱa复合物则是作为胶原的受体亦在血小板粘附过程中起作用。血小板膜糖蛋白在血小板止血过程中的作用如图1所示。 1981年回国
作用 GP53 CD62 * CD41即是GPIIb/IIIa的单抗又是GPIIb的单抗，CD61是GP IIIa的单抗 二、流式细胞术检测血小板活化 1、常规方法 由于血小板的活化程度可由血小板膜相关糖蛋白表达水平的高低来判断，FCM测定相关糖蛋白的表达情况就成为检查血小板功能的一种新手段。血小板活化时其质膜糖蛋白较其静止期发生显著改变，FCM可以通过单抗免疫荧光标记（如抗GPⅡb/Ⅲa、抗GPⅡb、抗GPⅢa、CD62P、CD63等）测定平均荧光强度或特异性荧光抗体结合阳性血小板的百分
