NBD-14189,2234273-72-2

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NBD-14189

CAS No. : 2234273-72-2

MCE 国际站：NBD-14189

产品活性：NBD-14189 是一种有效的 HIV-1 进入拮抗剂，对 HIV-1_HXB2 假病毒的 IC₅₀ 为 89nM。NBD-14189 与 HIV-1 gp120 结合并显示出强大的抗病毒活性 (EC₅₀<200 nM)。

研究领域：Anti-infection

作用靶点：HIV

In Vitro: NBD-14189 has anti-HIV-1 activity (IC₅₀=0.089 μM) and cytotoxicity (CC₅₀=21.9 μM) in single-cycle (TZM-bl cells) assays. NBD-14189 has anti-HIV-1 activity (IC₅₀=0.18 μM) and cytotoxicity (CC₅₀=22.1 μM) in multi-cycle (MT-2 cells) assays.
NBD-14189 (0-50 μM) prevents HIV-1 mediated cell-cell fusion with an IC₅₀ of 9.4 μM in indicator cells TZM-bl cells were cocultured with Env- and Tat-expressing HL2/3 cells.
NBD-14189 shows weak or no inhibition of the hERG current, with an IC₅₀ of 3.0 μM, respectively.

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