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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
2672489-14-2
- 规格:
1 mg
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Cereblon inhibitor 1
CAS No. : 2672489-14-2
MCE 国际站:Cereblon inhibitor 1
产品活性:Cereblon inhibitor 1 是一种异吲哚啉衍生物,一种 cereblon E3 泛素连接酶调节活性分子。 Cereblon inhibitor 1 具有用于癌症研究的潜力。
研究领域:PROTAC
作用靶点:Ligands for E3 Ligase
In Vitro: Cereblon inhibitor 1 (compound CM-48) suppresses MM.1S cell proliferation (IC50=0.0365 nM).
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文献和实验14-3-3 is a potent inhibitor of protein kinase C, but the N-terminal domain does not inhibit PKC activity. Site-specific mutagenesis of several regions in the tau isoform of 14-3-3, including the mutation of a putative pseudosubstrate site
Introduction of human 14-3-3 proteins
inhibitor of protein kinase C,but the N-terminal domain does not inhibit PKC activity.Site-specific mutagenesis of several regions in the tau isoform of 14-3-3,including the mutation of a putative pseudosubstrate site to a potential substrate sequence
Methods for Studying the Interaction of Barnase with Its Inhibitor Barstar
complex, with K d =10−14 M , half-life of about 2 d and an association rate constant of 4�108 M −1 /s. The kinetic and thermodynamics of the barnase-barstar interaction were investigated in detail (12 –20 ). High affinity is maintained at pH 7.0–
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