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CYP121A1-IN-1
MCE 国际站：CYP121A1-IN-1
产品活性：CYP121A1-IN-1 是一种有效的 CYP121A1 抑制剂，对抗结核分枝杆菌具有良好的活性 (H37Rv MIC90∼6.25 μM, ∼2.2 μg/mL)。CYP121A1-IN-1 通过抑制 CYP121A1 介导的环(l-酪氨酸-l-酪氨酸)转化为真菌环素，可显著减少真菌环素的产生。
研究领域：Metabolic Enzyme/Protease
作用靶点：Cytochrome P450
In Vitro: CYP121A1-IN-1 (compound 61) (0.78-400 μM; one week for c7H9 and 7H9-Low BSA media or two weeks for MMM-Ch medium) has favorable activity against Mtb strain H37Rv (MIC90∼6.25 μM, ∼2.2 μg/mL).
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文献和实验Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families
at an excitation wavelength of 370 nm and an emission wavelength of 450 nm. This method is applicable to enzymatic studies to determine the catalytic activity of cDNA-expressed human enzymes in the CYP1, CYP2, and CYP3 families, and 7-ethoxycoumarin O -deethylation
Use of 7-Ethoxycoumarinto Monitor Multiple Enzymesin the Human CYP1, CYP2, and CYP3 Families
in the human CYP1, CYP2, and CYP3 families are active catalysts of 7-ethoxycoumarin O-deethylation (3 ). Consequently, the 7-ethoxycoumarin O-deethylase assay has been used to verify the catalytic activity of a panel of recombinant human P450s in the CYPl, CYP
PLoS Genet. 2009 March; 5 (3) : e1000433. Published online 2009 March 20. doi: 10.1371/journal.pgen.1000433 A Genome-Wide Association Study Confirms VKORC1 , CYP2C9 , and CYP4F2 as Principal Genetic
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