Vinaxanthone,133293-89-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Vinaxanthone

CAS No. : 133293-89-7

MCE 国际站：Vinaxanthone

产品活性：Vinaxanthone (SM-345431) 是一种有效的选择性 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，semaphorin3A 和 FabI的 IC₅₀ 分别为 0.1-0.2 μM 和 0.9 μM。Vinaxanthone 抑制底物(t-o-NAC thioester)和辅助因子 (NADPH)，K_i 分别为 3.1 μM 和 1.0 μM。Vinaxanthone 能够用于处理由多重耐药病原体引起的感染。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Phospholipase  |  Bacterial

In Vitro: Vinaxanthone shows selective inhibitory activity against phospholipase C (PLC) from rat brain, mutine colon 26 Adenocarcinoma and murine fibroblasts NIH3T3 with IC₅₀s being 5.4, 9.3 and 44 μM, respectively.
Vinaxanthone (0.1 mg/mL, 24 h) enhances peripheral nerve regeneration and induces small amounts of neovascularization growth into the cornea.
Vinaxanthone (0.5 μM, 20 min) may protects from Dox-induced podocyte apoptosis.
Vinaxanthone (0.1-1 μM, 24 h) ameliorates the TGF-β1-induced tubular cell characteristic change.

In Vivo: Vinaxanthone (SM-345431) (0.1 mg/mL, Subconjunctival injections, every 2 days, 3 weeks) accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model.
Vinaxanthone (SEMA3A-I) (20 µg, i.p.) protects from Doxorubicin (HY-15142A)-induced podocyte injury through an anti-apoptosis mechanism in mouse model of Doxorubicin (HY-15142A)-induced podocytopathy.

相关产品：Rapamycin  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Dexamethasone  |  Puromycin dihydrochloride  |  Dimethyl sulfoxide  |  Staurosporine  |  Actinomycin D  |  G-418 disulfate  |  GW4869  |  Etoposide  |  5-Azacytidine  |  Nigericin sodium salt  |  Brefeldin A  |  Estradiol  |  CCCP  |  Ionomycin  |  Resveratrol  |  Hygromycin B  |  Tunicamycin  |  Mitomycin C  |  Everolimus  |  Doxycycline hyclate  |  Tacrolimus  |  Methotrexate  |  Neomycin sulfate  |  Acetaminophen  |  Streptozotocin  |  Anisomycin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds