Recombinant Human ACE-2 (C-6His)
Catalog #: DRA110 Derived From: Human Cells
Description:
Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a 6His tag at the C-terminus.
Accession: Q9BYF1
Names(Known as): Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Quality Control:
Mol Mass: 84.63kDa AP Mol Mass: 103kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE and SEC-HPLC.
SDS-PAGE: |
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SEC-HPLC: |
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Bioactivity-Elisa:
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Immobilized Human ACE-2-His(Cat#DRA110)at 10μg/ml (100μl/well) can bind 2019-nCoV S Protein RBD-mFc(Cat#DRA32). The ED50 of 2019-nCoV S Protein RBD-mFc(Cat#DRA32) is 19.97 ng/ml. |
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Formulation:
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4
Shipping:
The product is shipped on dry ice pack.
Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Application:
Immunogen, calibrator or standard.
Background:
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY