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Human IL-8 (诊断原料,感染类)
Recombinant Human IL-8
Catalog #: DC037 Derived From: E.coli
Description:
Recombinant Human Interleukin-8/IL-8 is produced by E.coli expression system and the target gene encoding Ala23-Ser99 is expressed.
Accession: P10145
Names(Known as):Interleukin-8; IL-8; C-X-C Motif Chemokine 8; Emoctakin; Granulocyte Chemotactic Protein 1; GCP-1; Monocyte-Derived Neutrophil Chemotactic Factor; MDNCF; Monocyte-Derived Neutrophil-Activating Peptide; MONAP; Neutrophil-Activating Protein 1; NAP-1; Protein 3-10C; T-Cell Chemotactic Factor; IL8; CXCL8
Quality Control:
Mol Mass: 8.9kDa AP Mol Mass: 11kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μm filtered solution of PBS, PH7.4.
Shipping:
The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Ion-exchange chromatography.
Immunoreactivity:
Confirmed by reaction with monoclonal antibodies specific to IL-8.
Application:
Immunogen, calibrator or standard.
Background:
Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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文献和实验感染类项目分析:PCT(降钙素原)与CRP(C-反应蛋白)比较
性胰腺炎分成三组,并检测血浆PCT、IL-8和CRP浓度,结果发现感染坏死组平均PCT和IL-8明显高于无菌坏死组,而CRP在两组间无差别。水肿性胰腺炎组三种指标均最低。通过ROC曲线统计分析,预测感染性坏死胰腺炎的最佳分界值PCT为.8ug/L,IL-8为112ug/L,以此分界值为基准预测感染性坏死胰腺炎PCT的敏感性、特异性,准确度分别为94%、g1%、92%,IL-8的敏感性、特异性、准确度分别为72%、75%、74%。相比之下,PCT与感染坏死性胰腺炎发生最为相关。 3、降钙素原参考
【摘要】如果未经治疗,大多数感染了人类免疫缺陷病毒(HIV)者最终进展为爱滋病患者。罕见个人('精英控制者')在未经治疗时维持艾滋病毒RNA在非常低的水平,从而使疾病恶化和传染的可能性不大。某些人类白细胞抗原I类等位基因在精英控制者富集,和检测到的HLA-B57最有相关性。由于HLA分子呈递病毒多肽,激活CD8 + T细胞,这是一种监控HIV的免疫介导机制。在这里,我们描述HLA - B57分子的多肽结合特性如何影响胸腺的发展,如此,相对于其他HLA限制性T细胞,在B57的限制克隆较大
因素。与对照组类器官相比,患者源性类器官中的极化神经前体细胞增殖减少、分化提前;此外,对照组类器官中 CDK5RAP2 的敲除导致了类似的表型,这表明 CDK5RAP2 功能的丧失是人类小头畸形症的病因之一【2】。这项研究是第一个使用脑类器官来模拟神经发育障碍的例子,并通过 CRISPR/Cas9 技术将脑类器官进行基因编辑,为人类了解脑类疾病的机制奠定了基础。 人类脑类器官模型同样为研究感染病的发病机制提供了生理学相关的平台。在 ZIKV 病毒肆虐期间,有人提出包括小头畸形在内的神经系统疾病可能
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