- 询价
- 近岸蛋白(Novoprotein)
- 中国
- DRA24
- 2025年11月04日
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Human GDF15(诊断原料,心肌标志物）
Recombinant Human GDF15
Catalog #: DRA24 Derived From: Human Cells
Description:
Recombinant Human GDF15 is produced by our Mammalian expression system and the target gene encoding Ala197-Ile308 is expressed with a HSA, 6His tag at the N-terminus.
Accession: Q99988
Names(Known as): GDF15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; PDF; PDFGDF-15; PLAB; PLABNRG-1
Quality Control:
Mol Mass: 81kDa AP Mol Mass: 80-90kDa, reducing conditions
Purity: Greater than 80% as determined by reducing SDS-PAGE.
Bioactivity-BLI:
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| Loaded Human GDF-15 Antibody 15E1-mFc(Cat#DA015) on AMQ Biosensor, can bind Human GDF15(Cat#DRA24) with an affinity constant of 2.24n M as determined in BLI assay. |
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Loaded Human GDF-15 Antibody 11B2-mFc(Cat#DA016) on AMQ Biosensor, can bind Human GDF15(Cat#DRA24) with an affinity constant of 3.00n M as determined in BLI assay. |
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| Loaded Human GDF-15 Antibody 9F3-mFc(Cat#DA017) on AMQ Biosensor, can bind Human GDF15(Cat#DRA24) with an affinity constant of 1.96 nM as determined in BLI assay. |
Formulation:
Supplied as a 0.2 μm filtered solution of 10mM NaAc, pH 4.0.
Shipping:
The product is shipped on dry ice pack.
Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), Placental Transforming Growth Factor beta, Prostate-derived Factor, and Placental Bone Morphogenetic Protein, is a divergent member of the TGF-beta superfamily. Similar to other TGF-beta family proteins, the GDF-15 proprotein is cleaved at a dibasic cleavage site (RxxR) to release the mature protein. The C-terminal domain of GDF-15 contains seven characteristic conserved cysteine residues necessary for the formation of the cysteine knot and the single interchain disulfide bond. Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein and signals through the heterodimeric receptor composed of TGF-beta RI/ALK-5 and TGF-beta RII. GDF-15 has been shown to have various functions, including inhibition of TNF-alpha production from lipopolysaccharide-stimulated macrophages and the induction of cartilage formation. GDF-15 also promotes neuronal survival, and hypothalamic expression of GDF-15 causes appetite suppression via modulation of Neuropeptide Y and Pro-opiomelanocortin levels. GDF-15 is cardioprotective via inhibition of platelet activation, limiting atherosclerosis, inhibiting CXCL1-induced neutrophil adhesion, regulating angiogenesis, and inhibiting norepinephrine-induced mycardial hypertrophy.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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