Recombinant Human Interleukin-

名称：Recombinant Human Interleukin-36 receptor antagonist protein(IL36RN)
 

产品详情

纯度：Greater than 95% as determined by SDS-PAGE.

内毒素：Less than 1.0 EU/μg as determined by LAL method.

生物活性：The ED50 as determined by its ability to inhibit IL-36 alpha, IL-36 beta or IL-36 gamma -induced IL-8 secretion in A431 human epithelial carcinoma cells is less than 500 ng/ml in the presence of 10 ng/mL of recombinant human IL-36 beta.

基因名：IL36RN

Uniprot No.：Q9UBH0

别名：AI413231; Family of interleukin 1 delta; FIL1; FIL1 delta; FIL1(DELTA); FIL1D; Fil1delta; I36RA_HUMAN; IL 1 delta; IL 1 related protein 3; IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta); Il 1h3; IL 1HY1; IL 1L1; IL 1ra homolog; IL 1ra homolog, IL1F5 (Canonical product IL 1F5a); IL 1RP3; IL-1 delta; IL-1-related protein 3; IL-1F5; IL-1HY1; IL-1L1; IL-1ra homolog 1; IL-1RP3; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; IL36RN; Interleukin 1 delta; Interleukin 1 family member 5 (delta); Interleukin 1 family member 5; Interleukin 1 HY1; Interleukin 1 like protein 1; Interleukin 1 receptor antagonist homolog 1; Interleukin 36 receptor antagonist; Interleukin-1 delta; Interleukin-1 family member 5; Interleukin-1 HY1; Interleukin-1 receptor antagonist homolog 1; Interleukin-1-like protein 1; Interleukin-36 receptor antagonist protein; MGC29840; PSORP; RP23-176J12.6

种属：Homo sapiens (Human)

蛋白长度：Full Length

来源：E.coli

分子量：16.9 kDa

表达区域：1-155aa

蛋白标签：Tag-Free

产品提供形式：Liquid or Lyophilized powder

 

功能：通过结合到受体IL1RL2并阻止其与辅受体IL1RAP的关联来抑制白介素-36 (IL36A,IL36B和IL36G)的活性。部分IL-36信号系统，被认为存在于上皮屏障中并参与局部炎症反应;类似于IL-1系统，它与IL-1共享共同受体。建议在皮肤炎症中发挥作用。可能参与对真菌病原体的先天免疫反应，如烟曲霉。可能通过招募SIGIRR来激活抗炎信号通路。

 

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