FLT3-IN-3 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3).{61858} It inhibits wild-type, FLT3D835Y, and FLT3 bearing internal-tandem duplication (FLT3-ITD; IC50s = 13, 8, and 3 nM, respectively). FLT3-IN-3 suppresses the growth of MV4-11 acute m
英文名:
SAN50900
库存:
10 mg, 100 mg, 250 mg, 50 mg
供应商:
Cayman
CAS号:
2229050-90-0
规格:
This biochemical is available in the following size(s) 500 mg - Please inquire
An FLT3 inhibitor; inhibits wild-type, FLT3D835Y, and FLT3-ITD (IC50s = 13, 8, and 3 nM, respectively); suppresses the growth of MV4-11 AML cells that express FLT3-ITD (GI50 = 7 nM); induces cell cycle arrest at the G1 phase and apoptosis in the same cells; reduces intratumor FLT3-ITD autophosphorylation in a MV4-11 mouse xenograft model at 10 mg/kg