BMS-299897 is an inhibitor of γ-secretase.{35888,57908,57909} It selectively cleaves the carboxy terminal fragment (CTF) of amyloid precursor protein (APP) over the Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively).{57908} BMS-299897
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
290315-45-6
A γ-secretase inhibitor; selectively cleaves APP CTF over Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively); reduces increases in Aβ42 levels induced by Aβ (25-35) in the mouse hippocampus at 0.1-1 nmol/animal; prevents deficits induced by Aβ (25-35) in the novel object recognition test when tested with a one-hour, but not a 24-hour, intertrial interval