Plecanatide is a peptide agonist of the guanylate cyclase C receptor.{62429} It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells e
英文名:
SP-304
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
规格:
This biochemical is available in the following size(s) 100 mg, 250 mg, 500 mg - Please inquire
A peptide agonist of the guanylate cyclase C receptor; stimulates cGMP production in T84 cells (EC50 = 170 nM); reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67 induced by DSS in cancer-prone Apc+/Min-FCCC mice at 10 ppm in the diet; suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity at 0.01 and 0.05 mg/kg