Ethacrynic acid is a loop diuretic with anticancer activity.{53194},{33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a
英文名:
MK-595|NSC 624008|NSC 85791
库存:
1 g, 10 g, 5 g
供应商:
Cayman
CAS号:
58-54-8
规格:
This biochemical is available in the following size(s) 1 mg, 5 mg, 500 µg - Please inquire
A loop diuretic with anticancer activity; inhibits the NKCC cotransporter in duck erythrocytes (IC50 = 0.18 mM); inhibits ATP-dependent chloride uptake in rat renal plasma membrane vesicles at 0.3 mM; inhibits GSTP1-1 and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively); inhibits Wnt/β-catenin signaling in a cell-based reporter assay; cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively); increases tumor growth reduction induced by afatinib or neratinib in a 4T1 murine breast cancer model at 250 μg per day