XL147 is an inhibitor of class I PI3Ks (IC50s = 0.039, 0.036, 0.023, and 0.383 µM for p110α, -δ, -γ, and -β, respectively).{65046} It is selective for class I PI3Ks over the class III PI3K vacuolar protein sorting 34 (Vps34; IC50 = 6.974 µM), as well as
英文名:
Pilaralisib|SAR245408
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
934526-89-3
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
A class I PI3K inhibitor (IC50s = 0.039, 0.036, 0.023, and 0.383 µM for p110α, -δ, -γ, and -β, respectively); selective for class I PI3Ks over Vps34, DNA-PK, and mTOR (IC50s = 6.974, 4.75, and >15 µM, respectively); inhibits proliferation of MCF-7 and PC3 cells (IC50s = 9.669 and 16.492 µM, respectively); reduces tumor growth in a BT474 breast cancer mouse xenograft model when administered alone or in combination with trastuzumab or lapatinib