ACHP is an inhibitor of IκB kinase β (IKKβ) and IKKα (IC50s = 8.5 and 250 nM, respectively).{57115} It is selective for IKKβ and IKKα over IKKγ, Syk, and MKK4 (IC50s = >20 µM for all). It reduces the constitutive phosphorylation of IκBα and NF-κB p65 in
库存:
1 mg, 5 mg
供应商:
Cayman
CAS号:
406208-42-2
规格:
This biochemical is available in the following size(s) 1 mg, 10 mg, 5 mg - Please inquire
An inhibitor of IKKβ and IKKα (IC50s = 8.5 and 250 nM, respectively); selective for IKKβ and IKKα over IKKγ, Syk, and MKK4 (IC50s = >20 µM for all); reduces the constitutive phosphorylation of IκBα and NF-κB p65 in U266 and NCU-MM-2 cells at 50 µM; prevents TNF-α-induced activation of NF-κB in U266 cells at 0.1 µM; inhibits the growth of U266, NCU-MM-2, ILKM2, and BJAB cells (IC50s = 18.3, 27.6, 34.6, and 17.6 µM, respectively); prevents TNF-α-induced HIV-1 replication in latently HIV-1-infected OM10.1 cells (EC50 = 0.56 µM); prevents PMA-and imiquimod-induced skin inflammation in mice at 5 mg/kg