- ￥363 - 1250
- MedChemExpress(MCE)
- 美国
- HY-131723
- 2025年07月14日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥880.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥363.0 |
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1250.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Pregnenolone 16α-carbonitrile
CAS No. : 1434-54-4
MCE 国际站：Pregnenolone 16α-carbonitrile
产品活性：Pregnenolone 16α-carbonitrile 是一种具有口服活性的典型和有效的啮齿动物 PXR 激活剂。Pregnenolone 16α-carbonitrile 是一种合成类固醇，可诱导细胞色素 P450 3A 的表达。Pregnenolone 16α-carbonitrile 对随后的应激性损伤表现出更强的耐受性。
研究领域：Metabolic Enzyme/Protease
作用靶点：Cytochrome P450
In Vitro: Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P450 3A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults.
In Vivo: Pregnenolone 16α-carbonitrile (40 mg/kg/day; i.p.; for two days) induces the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice.
?Pregnenolone 16α-carbonitrile (100 mg/kg; ip; single dose) induces the expression of CYP3A mRNA in adult female Sprague-Dawley rats weighing 150-200 g.
?Pregnenolone 16α-carbonitrile (35 mg/kg; gavage; once daily for three days) increase in Pgp expression in male Sprague-Dawley rats, aged approximately 100 days and weighing 250-400 g.
相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Orally Active Compound Library | Mitochondria-Targeted Compound Library | Verapamil | Apigenin | Fenofibrate | Chlorpromazine hydrochloride | Ketoconazole | 1-Aminobenzotriazole | Letrozole | Abiraterone | Itraconazole | Cepharanthine | Quinidine (15% dihydroquinidine) | Diosmetin | Clarithromycin | Naringin | Gemfibrozil 1-O-β-glucuronide | Atovaquone | Fomepizole | Talarozole | Cobicistat | Salvianolic acid C | Hypericin | Methoxsalen | Sulfaphenazole | (S)-Mephenytoin | Furafylline | Anastrozole | Gemfibrozil
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验甾类（化合物）16α-羟化酶 steroid 16α－hydr－oxylase
甾类（化合物）16α-羟化酶 steroid 16α－hydr－oxylase 存在于肝脏、人睾丸微粒体的于甾类的16α位置上引入羟基的酶，需要有分子态氧和NADPH。例如脱氢表雄甾酮在肝脏中将16α位羟基化后，在胎盘中形成雌甾三醇。
Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease
from circulating androstenedione (15) secreted by the adrenal cortex (16). Of these two estrogens, 17β-estradiol is the more biologically active. In the placenta, estriol is synthesized from its precursor, 16α-hydroxydehydroisoandrosterone, and this substrate
C18 H24 O3 ，雌甾 -1， 3， 5（ 10） -三烯 -3， 16α， 17β -三醇。是一种性激素，可从妊妇尿中检出。雌激素的作用比雌酮弱。在胎儿的肾上腺里生成的脱氢表雄酮，在肝脏里经 16α羟基化后，在胎盘里芳构化而成为雌三醇。随着妊娠的进行，在尿中的排出量逐渐增加，至分娩后锐减。作为缓和的性激素试剂，经口服可治疗更年期障碍等。
技术资料暂无技术资料 索取技术资料
