- ￥433 - 5990
- TargetMol
- 美国
- T6296
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
RAF265
- 库存：
10
- 供应商：
TargetMol
- CAS号：
927880-90-8
- 规格：
1 mL/5 mg/50 mg/25 mg/1 mg/10 mg/2 mg/100 mg
| 规格： | 1 mL | 产品价格： | ￥1130.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥937.0 |
| 规格： | 50 mg | 产品价格： | ￥4180.0 |
| 规格： | 25 mg | 产品价格： | ￥2830.0 |
| 规格： | 1 mg | 产品价格： | ￥433.0 |
| 规格： | 10 mg | 产品价格： | ￥1490.0 |
| 规格： | 2 mg | 产品价格： | ￥623.0 |
| 规格： | 100 mg | 产品价格： | ￥5990.0 |
Product Introduction
Bioactivity
英文名:RAF265
描述:RAF265 (CHIR-265) (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.
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文献和实验The Raf-1 serine/threonine protein kinase is a central component of the Ras/Raf/MEK/MAP kinase cascade, a highly conserved signaling pathway responsible for the transmission of signals emanating from cell surface growth factor, cytokine
Monitoring Oncogenic B-RAF-Induced Senescence in Melanocytes
The B-RAF kinase is a downstream effector of the RAS family of proto-oncogenes and is constitutively activated in the majority of human melanomas. The common oncogenic B-RAFV600E mutant cooperates with additional genetic lesions to transform
Raf-1 Protein Kinase Activity in T Cells from Aged Mice
Most of our models of signal transduction through the T-cell receptor (TCR) involve components and pathways first described in T-cell clones and T-cell lymphomas such as the Jurkat cell line (1 ). These studies, while providing valuable
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