- ￥3200 - 5910
- TargetMol
- 美国
- T27167
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Diclofenac Acyl Glucuronide
- 库存：
10
- 供应商：
TargetMol
- CAS号：
64118-81-6
- 规格：
500 μg/1 mg
| 规格： | 500 μg | 产品价格： | ￥3200.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥5910.0 |
Product Introduction
Bioactivity
英文名:Diclofenac Acyl Glucuronide
描述:Diclofenac Acyl Glucuronide is a major biliary metabolite of Diclofenac (GLXC-07892), a nonsteroidal antiinflammatory drug and COX inhibitor.
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文献和实验In Vitro Assessment of the Reactivity of Acyl Glucuronides
glucuronides are prepared with UDPGA-fortified microsomes and 1-O-β acyl glucuronide is established based on its sensitivity to hydrolysis by β-glucuronidase. The chemical degradation of 1-O-β isomer in 0.1 M phosphate buffer at pH 7.4 is monitored over time
In Vitro Screening Assay of the Reactivity of Acyl Glucuronides
Acyl glucuronides are unstable at physiologic pH and thus can result in free aglycone by hydrolysis and lead to positional isomers by acyl migration. Acylmigrated glucuronide isomers were shown to bind covalently to proteins in vitro
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