别 名:BACE1 (phospho-Ser498); BACE1 (phospho-S498); p-BACE1 (Ser498); p-BACE1 (Se498); APP beta secretase; Asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE; Beta secretase 1; Beta secretase; Beta site amyloid beta A4 precursor protein cleaving enzyme; Beta site amyloid precursor protein cleaving enzyme 1; Beta site amyloid precursor protein cleaving enzyme; Beta site APP cleaving enzyme 1; Beta site APP cleaving enzyme; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Memapsin 2; Memapsin2; Membrane associated aspartic protease 2; Transmembrane aspartic proteinase Asp2; BACE1_HUMAN; Beta-secretase 1; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Membrane-associated aspartic protease 2.
分 子 量:51kDa
细胞定位:细胞浆
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:β-淀粉样肽的脑沉积是阿尔茨海默病的早期和关键特征。 淀粉样β肽是由两种蛋白酶对淀粉样前体蛋白(APP)进行蛋白水解切割而产生的,其中一种是由该基因编码的蛋白质。 编码的蛋白质是肽酶 A1 蛋白家族的成员,是一种 I 型整合膜糖蛋白和天冬氨酸蛋白酶,主要存在于高尔基体中。 已针对该基因描述了编码不同同种型的多个转录变体。
Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.