储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:该基因编码在 B 细胞发育中起关键作用的细胞质接头或衔接蛋白。 该蛋白将 B 细胞受体相关激酶激活与下游信号通路联系起来,从而影响各种生物学功能。 五个酪氨酸残基的磷酸化是该蛋白质在 B 细胞受体激活后使不同的信号效应子成核所必需的。 该基因的突变导致低球蛋白血症和缺乏 B 细胞,这是一种疾病,其中原 B 细胞向前 B 细胞的转变在发育过程中受阻。 在一些前 B 型急性淋巴细胞白血病病例中也显示出这种蛋白质的缺乏。 已经发现了该基因的选择性剪接转录变体。
Function: Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.