别 名:Bcl-6/5; Bcl-6+Bcl-5; B-cell lymphoma 6 protein isoform 1; zinc finger transcription factor BCL6S; B-cell lymphoma 6 protein transcript; BCL-5; BCL6; Bcl 6; protein LAZ-3; B-cell lymphoma 5 protein; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; zinc finger protein 51; cys-his2 zinc finger transcription factor; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51; BCL6_HUMAN.
分 子 量:78kDa
细胞定位:细胞核
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:该基因编码的蛋白质是一种锌指转录因子,含有一个 N 端 POZ 结构域。 这种蛋白质作为转录的序列特异性阻遏物,并已被证明可以调节 B 细胞的 START 依赖性 IL-4 反应的转录。 这种蛋白质可以与多种含有 POZ 的蛋白质相互作用,这些蛋白质起到转录辅阻遏物的作用。 发现该基因在弥漫性大细胞淋巴瘤(DLCL)中频繁易位和超突变,可能与DLCL的发病机制有关。 已发现该基因的编码不同蛋白质同种型的选择性剪接转录变体。
Function: Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
Subunit: Homodimer. Interacts (via BTB domain) with BCOR; the interaction is direct. Interacts (via BTB domain) with NCOR2; the interaction is direct. Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.