别 名:Activin Receptor Type IA; Activin A receptor type I; Activin A receptor type II like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR1; ACTR 1; ACTR-1; ACTR-I; ACTRI; ACVR 1; ACVR1; ACVR1_HUMAN; ACVR1A; ACVRLK 2; ACVRLK2; ALK 2; ALK-2; ALK2; FOP; Hydroxyalkyl protein kinase; Serine/threonine protein kinase receptor R1; Serine/threonine-protein kinase receptor R1; SKR 1; SKR1; TGF-B superfamily receptor type I; TGFB superfamily receptor type I; TSR-I; TSRI; TSRI.
分 子 量:55kDa
细胞定位:细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:转化生长因子 b 超家族的成员与一对跨膜蛋白(称为 I 型和 II 型受体)结合,它们含有丝氨酸/苏氨酸激酶并结合形成信号复合物 (1)。 已显示激活素与异聚非共价复合物结合,该复合物由 I 型受体 ACTR-IA(也称为 ACVRI 和 ALK-2)或 ACTR-IB(也称为 ALK-4 和 SKR2)和 II 型受体组成 ,ACTR-IIA(也称为 ACVR2A)或 ACTR-IIB(也称为 ACVR2B)(1-6)。 两种受体类型都在脑中高度表达 (5)。 激活素受体家族成员被认为以剂量依赖性方式介导对基因表达、细胞分化和形态发生的不同影响 (5,6)。
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
Subunit: Interacts with FKBP1A. Interacts with FCHO1.