Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cell membrane Cytoplasm
免疫原
Synthetic Peptide
亚型
IgG1
纯化方法
Affinity purification
克隆号
8H7
背景资料
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
克隆类型
Monoclonal Antibody
交叉反应
Human
应用
IHC
规格
50ul 100ul
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
Immunohistochemistry of paraffin-embedded Human colorectal cancer with MLKL antibody diluted at 1:80