Anti-MLKL Monoclonal Antibody

Anti-MLKL Monoclonal Antibody


产品简介

英文名称	Anti-MLKL Monoclonal Antibody
别名	hMLKL;MLKL
宿主	Mouse
稀释比例	IHC 1:50-200.
Gene ID	197259
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q8NB16
蛋白分子量	30/54kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cell membrane Cytoplasm
免疫原	Synthetic Peptide
亚型	IgG1
纯化方法	Affinity purification
克隆号	8H7
背景资料	This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
克隆类型	Monoclonal Antibody
交叉反应	Human
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human colorectal cancer with MLKL antibody diluted at 1:80