Anti-CNOT3 Polyclonal Antibody

Anti-CNOT3 Polyclonal Antibody


产品简介

靶标	CNOT3
别名	CCR4 associated factor 3; CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CNOT3; CNOT3_HUMAN; KIAA0691; LENG2; NOT3; NOT3H
宿主	Rabbit
稀释比例	IHC 1:50-200.
Gene ID	4849
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O75175
蛋白分子量	82kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	A synthetic peptide of human CNOT3
亚型	IgG
纯化方法	Affinity purification
背景资料	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
Public Immunogen Range	270-320/753aa
克隆类型	Polyclonal Antibody
交叉反应	Human Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human colorectal cancer with CNOT3 antibody diluted at 1:100.