Anti-SS18L1 Polyclonal Antibod

Anti-SS18L1 Polyclonal Antibody


产品简介

英文名称	Anti-SS18L1 Polyclonal Antibody
靶标	SS18L1
别名	SS18-like protein 1;SYT homolog 1;CREST; KIAA0693;
宿主	Rabbit
稀释比例	IHC 1:50-200.
Gene ID	26039
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O75177
蛋白分子量	29/34/41/43kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Nucleus Cytoplasm
免疫原	Recombinant protein of human SS18L1
亚型	IgG
纯化方法	Affinity purification
背景资料	Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
Public Immunogen Range	1-350aa
克隆类型	Polyclonal Antibody
交叉反应	Human Predicted:Bovine Rat Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human thyroid cancer with SS18L1 antibody diluted at 1:100