Anti-BTBD12 Polyclonal Antibod

Anti-BTBD12 Polyclonal Antibody


产品简介

英文名称	Anti-BTBD12 Polyclonal Antibody
靶标	HAUS6
别名	BTBD12, KIAA1784, KIAA1987
宿主	Rabbit
稀释比例	WB 1:1000-3000.
Gene ID	84464
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q8IY92
蛋白分子量	166/200kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Nucleus
免疫原	Recombinant protein of human BTBD12
亚型	IgG
纯化方法	Affinity purification
背景资料	Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
Public Immunogen Range	1-350aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with BTBD12 antibody diluted at 1:2000;Lane:HMC-1,A549