Anti-TMEM30A Polyclonal Antibo

Anti-TMEM30A Polyclonal Antibody



产品简介

英文名称	Anti-TMEM30A Polyclonal Antibody
别名	C6orf67;CDC50A;Cell cycle control protein 50A;FLJ10856;P4 ATPase flippase complex beta subunit TMEM30A;TMEM30A;
宿主	Rabbit
稀释比例	WB 1:500-2000. IHC 1:25-100.
Gene ID	55754
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9NV96
蛋白分子量	28/37/41kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	Recombinant protein of human TMEM30A
亚型	IgG
纯化方法	Affinity purification
背景资料	Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.
Public Immunogen Range	1-326aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with TMEM30A antibody diluted at 1:1000;Lane: HepG2,HeLa,U251

Immunohistochemistry of paraffin-embedded Human endometrial cancer with TMEM30A