Anti-SLC8B1 Polyclonal Antibod

Anti-SLC8B1 Polyclonal Antibody


产品简介

英文名称	Anti-SLC8B1 Polyclonal Antibody
别名	NCKX6;NCLX;SLC24A6
宿主	Rabbit
稀释比例	IHC 1:50-200.
Gene ID	80024
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q6J4K2
蛋白分子量	58/64kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	A synthetic peptide of human SLC8B1
亚型	IgG
纯化方法	Affinity purification
背景资料	Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+?entry (SOCE) and Ca2+?release-activated Ca2+?(CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+?in exchange of either Li+?or Na+, explaining how Li+?catalyzes Ca2+?exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+?(PubMed:15060069).
Public Immunogen Range	25-75/584aa
克隆类型	Polyclonal Antibody
交叉反应	Human
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human colorrectal cancer with SLC8B1 antibody diluted at 1:80