Anti-ELL3 Polyclonal Antibody

Anti-ELL3 Polyclonal Antibody



产品简介

靶标	ELL3
别名	Elongation factor RNA polymerase II-like 3;FLJ22637;RNA polymerase II elongation factor ELL3
宿主	Rabbit
预测交叉反应	Bovine
稀释比例	WB 1:1000-3000.
Gene ID	80237
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9HB65
蛋白分子量	40/45kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	Recombinant protein of human ELL3
亚型	IgG
纯化方法	Affinity purification
背景资料	Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).
Public Immunogen Range	1-350aa
克隆类型	Polyclonal Antibody
应用	WB
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with ELL3 antibody diluted at 1:2000;Lane:Caski,Mouse testis