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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
55
- 靶点:
/
- 级别:
科研
- 目录编号:
KT1283
- 克隆性:
多克隆
- 抗原来源:
/
- 保质期:
1年
- 抗体英文名:
ARHGAP24
- 抗体名:
Rabbit Anti-ARHGAP24 antibody
- 标记物:
详询
- 宿主:
兔
- 适应物种:
(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
- 免疫原:
KLH conjugated synthetic peptide derived from human ARHGAP24: 501-600/748
- 亚型:
IgG
- 形态:
Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
50ul
中文名称:Rho GTP酶激活蛋白24抗体
英文名称:ARHGAP24
别 名:ARHGAP24; Filamin A associated RhoGAP; FILGAP; p73; p73RhoGAP; RAC1 and CDC4 specific GTPase activating protein of 72kDa; RCGAP72; Rho GTPase activating protein 24; Rho type GTPase activating protein 24; Rho GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY SAR 88; RHG24_HUMAN.
分 子 量:84kDa
细胞定位:细胞浆 细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

产品介绍:ARHGAP24 是一种 rho GTPase 激活蛋白,参与细胞极性、细胞形态和细胞骨架组织。 它作为 Rac 型 GTPase 的 GTPase 激活剂,将其转换为非活动的 GDP 结合状态。 它通过使 Rho 下游的 Rac 失活来控制肌动蛋白重塑,从而抑制前缘突出并促进细胞收缩以实现细胞极性。 有五种不同的异构体。异构体1在肾脏中广泛表达,水平较高。 异构体 2 主要在内皮细胞中表达并参与血管生成的调节。
Function:
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
注意:
所提供的本产品仅供研究使用,不得用于人类、治疗或诊断应用。


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文献和实验drlxg 诸位战友,因课题需要进行小鼠标本的RhoA、RhoC、Rac1蛋白的免疫组化染色,但查过多家公司的抗体,大多用于westernbot、免疫荧光等试验方法,极少直接标明可用于免疫组化,请问可否能用适合免疫荧光的抗体做免疫组化染色?另不知哪位能有上述三种抗体或其一,因经费紧张买不起大包装的抗体呀!多谢!!:) dianaofyezi 可以试试用免疫荧光的抗体做IHC,但是如果抗体的供货商没有明确标明能够做IHC
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