别 名:Ran; Androgen receptor associated protein 24; ARA 24; ARA24; Gsp1; GTP binding nuclear protein RAN; GTPase Ran; LPS; RAN member RAS oncogene family; Ras like protein TC4; Ras related nuclear protein; RASL2 8; TC 4; TC4; RAN_HUMAN.
货号:YLK-KT0919
分 子 量:24kDa
细胞定位:细胞核 细胞浆
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:Ran(ras 相关核蛋白)是一种小 GTP 结合蛋白,属于 RAS 超家族,对于 RNA 和蛋白质通过核孔复合物的易位至关重要。 Ran 蛋白还参与控制 DNA 合成和细胞周期进程。 Ran 的核定位需要存在染色体浓缩 1 (RCC1) 的调节因子。 Ran中的突变会破坏DNA合成。由于它的许多功能,Ran 很可能与其他几种蛋白质相互作用。 Ran 调节微管网络的形成和组织,与其在大分子的细胞核-胞质溶胶交换中的作用无关。 Ran 可能是有丝分裂过程中调节微管聚合的关键信号分子。 RCC1 在染色质周围产生高浓度的 Ran-GTP,进而诱导微管的局部成核。 Ran 是一种雄激素受体 (AR) 共激活剂,它与雄激素受体内不同长度的多聚谷氨酰胺有差异地结合。 AR 中的聚谷氨酰胺重复扩增与肯尼迪病(X 连锁脊髓和延髓肌萎缩)有关。 AR 的共激活随着 AR 内多谷氨酰胺的扩增而减少,这种弱共激活可能导致肯尼迪病发展过程中部分雄激素不敏感。
Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ surviving plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.