CAY10502,888320-29-4

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CAY10502

CAS No. : 888320-29-4

MCE 国际站：CAY10502

产品活性：CAY10502 是一种有效的钙依赖性胞质磷脂酶 A2 α (cPLA₂α) 抑制剂，对分离的酶具有 IC₅₀ 为 4.3 nM。CAY10502 可用于视网膜病变和炎症性疾病的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: CAY10502 inhibits the release of arachidonic acid mediated by cPLA2R stimulanted with A23187 and TPA in human platelets, with IC₅₀s of 0.57 and 0.0009 μM, respectively.
?CAY10502 (5, 20, 50 nM; 12 hours; müller cells) inhibits normoxic- and hypoxia-induced Prostaglandin E₂ (PGE₂) and VEGF production.
?CAY10502 (0.1-100 nM; 24 hours) inhibits the VEGF-induced proliferation of rat retinal microvascular endothelial cells (RRMEC).
?CAY10502 (10 μM) inhibits arachidonic acid (AA) release from the phospholipid pools, abrogated extremely low-frequency electromagnetic fields (ELF-EMF; 1 h) induced AA increase and the ELF-EMF inhibitory effect of Cav3.2 channels.

In Vivo: CAY10502-injected (2.5, 25, 100 nM; 5 μL) eyes demonstrates a dose-dependent inhibition of retinal neovascularization (NV) in rat oxygen-induced retinopathy (OIR).

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