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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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| 规格： | 1 mg | 产品价格： | ￥836.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2000.0 |
| 规格： | 10 mg | 产品价格： | ￥3600.0 |
| 规格： | 25 mg | 产品价格： | ￥5850.0 |
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VAS 3947
CAS No. : 869853-70-3
MCE 国际站：VAS 3947
产品活性：VAS 3947 是一种特异的 NADPH 氧化酶 (NOX) 抑制剂，具有强大的抗血小板作用。VAS 3947 通过 UPR 激活，主要由于蛋白质聚集和错误折叠，独立于抗 NOX 活性诱导细胞凋亡 (apoptosis)。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：NADPH Oxidase | Apoptosis
In Vitro: VAS3947 consistently inhibits NADPH oxidase activity in low micromolar concentrations, and interferes neither with ROS detection nor with XOD or eNOS activities. VAS3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection. In CaCo-2 cell homogenates, VAS3947 completely blocks NADPH-dependent ROS production with an IC50 of 12 µM.
VAS3947 triggers cell proliferation arrest and death independently of anti-NOX activity. The IC50 values of the different cell lines ranges from 2.6 ± 0.6 µM for the most sensitive cell line MV-4-11 to 4.9 µM for THP-1, the least sensitive.
VAS3947 decreases ROS levels. VAS3947 triggers endoplasmic reticulum (ER) stress and consequent unfolding protein response (UPR).
VAS3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3].
In Vivo: NADPH 氧化酶抑制剂
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文献和实验运送精子的管道，共两条。为附睾管尾端的直接延续。全长约 50cm，左侧较右侧稍长。管壁厚，管腔细小，管壁可分为粘膜、肌层和外膜三层。粘膜形成几条纵行皱襞，向管腔突起，到输精管壶腹部，皱襞渐渐变为许多薄而不规则的突起。上皮为假复层柱状，表面附有不动的纤毛，固有膜的结缔组织中含较多弹性纤维和血管。平滑肌层有内纵行、中环行、外纵行三层，肌层有力的收缩，有助于推动精子前进。外膜由疏松结缔组织形成，富血管和神经。
简称精管，是将精子从精巢到生殖孔的输送管。在脊椎动物，中肾管的一部或全部成为输精管。但是，在硬骨鱼类则有不同，它另有单独的管道在精巢间膜中形成输精管。在软骨鱼类和两栖类的中肾即与此成体肾脏相关的中肾管同时也是排尿管，但在羊膜类则专用于排出精子。睾丸内的细精管和输精管结合成的输精小管，在发生上是由若干残留的中肾小管分化而形成的。另外在输精管起始部显著弯曲，和输精小管结合构成副睾。副睾的输精管通常称为副睾管。其末端多分化为射精管。此种场合，从广义的输精管除掉副睾管和射精管的部分称为输精
The Bioassay of Cannabinoids Using the Mouse Isolated Vas Deferens
The mouse isolated vas deferens is a nerve-smooth muscle preparation that serves as a highly sensitive and quantitative functional in vitro bioassay for cannabinoid CB1 receptor agonists. Additionally, it is commonly used as a bioassay
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